Hydroxychloroquine enhances the antitumor effects of BC001 in gastric cancer
Identifieur interne : 000768 ( Main/Exploration ); précédent : 000767; suivant : 000769Hydroxychloroquine enhances the antitumor effects of BC001 in gastric cancer
Auteurs : Wei Wang ; Linqing Liu ; Yucheng Zhou ; Qiang Ye ; Xiuli Yang ; Jinying Jiang ; Ziqi Ye [République populaire de Chine] ; Feng Gao [République populaire de Chine] ; Xiaolu Tan [République populaire de Chine] ; Guobing Zhang ; Qingxia Fang ; Zixue XuanSource :
- International Journal of Oncology [ 1019-6439 ] ; 2019.
Abstract
Gastric cancer is an important cancer type worldwide, the anti-angiogenic agent BC001 can target the vascular endothelial growth factor receptor 2 (VEGFR2), and significantly suppresses the growth of gastric cancer BGC823 cells
Url:
DOI: 10.3892/ijo.2019.4824
PubMed: 31268153
PubMed Central: 6615922
Affiliations:
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<series><title level="j">International Journal of Oncology</title>
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<front><div type="abstract" xml:lang="en"><p>Gastric cancer is an important cancer type worldwide, the anti-angiogenic agent BC001 can target the vascular endothelial growth factor receptor 2 (VEGFR2), and significantly suppresses the growth of gastric cancer BGC823 cells <italic>in vitro</italic>
and <italic>in vivo</italic>
. However, numerous results indicated that antiangiogenic drugs could induce autophagy, and the inhibition of autophagy enhanced the anticancer effects of antiangiogenic agents. In the present study, hydroxychloroquine (HCQ), an inhibitor of autophagy, enhanced the antiproliferative and proapoptotic effects of BC001 <italic>in vitro</italic>
. Furthermore, HCQ enhanced the antitumor effects of BC001 on BGC823 xenograft tumors <italic>in vivo</italic>
. Of note, BC001 neither induced nor inhibited autophagy. RNA-sequencing results revealed that HCQ regulated autophagy or lysosomal-associated genes, such as tumor protein p53-inducible nuclear protein 1, interleukin (IL)1B, tumor necrosis factor (TNF), Mediterranean fever, ubiquitin specific peptidase 36, IL6, neuraminidase (NEU)1, ATP-binding cassette subfamily A member 1, proprotein convertase subtilisin/kexin type 9, myelin basic protein and NEU3. Importantly, HCQ was determined to affect multiple pathways, including 'negative regulation of endothelial cell proliferation', 'blood vessel remodeling', 'cell surface receptor signaling pathways' and 'notch receptor processing' associated with 'signal transduction', 'cancers' and 'immune system', through regulating C-X-C motif chemokine ligand 8, TNF, IL6, intercellular adhesion molecule 1 and FOS genes. In summary, HCQ was proposed to enhance the anticancer effects of BC001 in gastric cancer via complex mechanisms.</p>
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</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Zhejiang</li>
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<settlement><li>Hangzhou</li>
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<name sortKey="Liu, Linqing" sort="Liu, Linqing" uniqKey="Liu L" first="Linqing" last="Liu">Linqing Liu</name>
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<name sortKey="Ye, Qiang" sort="Ye, Qiang" uniqKey="Ye Q" first="Qiang" last="Ye">Qiang Ye</name>
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</tree>
</affiliations>
</record>
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